Caryophyllene and beta-caryophyllene are best known for their sharp bite and spicy black pepper aroma. Unsurprisingly, this terpene can also be found in black pepper, cinnamon, cloves, and aromatic spices like oregano, basil, and rosemary. There are many benefits to this terpene, including anti-bacterial, antifungal, and antiseptic properties. It also has very powerful anti-inflammatory properties and due to this, caryophyllene will often be found in many topicals and creams. Some studies have used caryophyllene in alcohol rehabilitation studies, with some promise. Mice-based research showed that when administered caryophyllene, there was a reduction in voluntary alcohol intake. Future research will be done to test caryophyllene’s role in treating alcohol withdrawal symptoms.
Unlike any other terpene, B-caryophyllene can bind to CB2 receptors in the endocannabinoid system. This makes it both a terpene and a cannabinoid!